HORMONAL TREATMENT

Estrogen Gel

Estrogen gel is a topical hormone replacement therapy that can effectively alleviate menopausal symptoms by providing a steady release of estrogen directly through the skin.

*Content reviewed by HotPause Health Medical Advisor & Doctor of Pharmacy Audrey Hou, PharmD, CMPP

Estrogen gel is a topical hormone replacement therapy used to treat specific symptoms of menopause. As women approach menopause, the body’s natural production of estrogen decreases, leading to various uncomfortable symptoms, such as hot flashes, night sweats, vaginal dryness, and mood changes. Therapeutic expert and doctor of pharmacy, Audrey Hou, explains why estrogen gel offers a convenient way to deliver estrogen directly through the skin, helping to alleviate these symptoms.

How Estrogen Gel Works

Estrogen gels, such as Elestrin and EstroGel, are applied directly to the skin, usually on the arms, legs, or abdomen. The gel is absorbed through the skin, introducing estrogen into the bloodstream. This method of delivery helps to restore estrogen levels to a more stable state, which can reduce the severity of menopause symptoms. The transdermal application also allows for the estrogen to be absorbed gradually, mimicking the body’s natural rhythms more closely than some other forms of hormone replacement therapy (HRT).

Potential Benefits of Estrogen Gel for Menopause

• Reduction of menopausal symptoms
• Fewer hot flashes and reduced vaginal dryness
• Improvement in mood
• Positive effects on bone density, potentially reducing the risk of osteoporosis
• Lower systemic estrogen levels compared to oral estrogen due to topical application
• Potentially reduced risk of certain side effects compared to oral estrogen

Usage and Considerations

Estrogen gel is prescribed by a healthcare provider, who will recommend a specific dosage and application routine. The gel is applied to clean, dry skin, and it’s important to follow the provider’s instructions carefully to ensure effective absorption and minimize the risk of transferring the gel to others through skin contact.

Side Effects and Considerations

While estrogen gel can be a safe and effective treatment for many women, there are potential side effects, including skin irritation at the application site, nausea, headache, unexpected vaginal bleeding or spotting, and breast tenderness among others. Women with a history of breast cancer, uterine cancer, or those at risk for cardiovascular disease should discuss these risks thoroughly with their healthcare provider.

Conclusion

Estrogen gel can be a viable option for managing menopause symptoms with the convenience of topical application and the benefit of steady estrogen absorption. It can offer symptomatic relief with a favorable side effect profile, making it an attractive choice for women seeking to mitigate the impact of menopause on their daily lives. If you’re experiencing menopausal symptoms, consult your healthcare provider to determine if estrogen gel is a suitable treatment option for you.

References:

1. Elestrin [package insert]. Lincolnshire, IL: BioSante Pharmaceuticals, Inc.; 2006. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021813lbl.pdf
2. Estrogel [package insert]. Herndon, VA: ASCEND Therapeutics US, LLC; 2014. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021166s010lbl.pdf

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.