NON-HORMONAL TREATMENT

Prasterone

Prasterone is used to treat women with moderate to severe dyspareunia (painful intercourse) due to menopause.

*Content reviewed by Audrey Hou, PharmD, CMPP

Prasterone, also known as dehydroepiandrosterone (DHEA), is a naturally occurring hormone that serves as a precursor to both estrogen and testosterone. As women enter menopause, hormone levels fluctuate and often decrease, leading to a variety of symptoms such as vaginal dryness, decreased libido, and mood swings. Prasterone supplementation is increasingly being explored as a potential treatment to alleviate these symptoms and improve overall quality of life during menopause.

How Prasterone Works

Prasterone is produced by the adrenal glands and is one of the most abundant steroid hormones in the body. It plays a key role in hormone production and is converted into estrogen and testosterone as needed. During menopause, as the body’s natural production of these hormones declines, supplementing with prasterone can help maintain hormonal balance. This can lead to an improvement in symptoms that are exacerbated by lower hormone levels.

Potential Benefits of Prasterone for Menopause

• Vaginal Health: Prasterone has been shown to effectively alleviate symptoms of vaginal atrophy, such as dryness, itching, and discomfort during intercourse. It helps improve the thickness and elasticity of vaginal tissues and enhances natural lubrication.
• Sexual Function: By supporting healthy levels of estrogen and testosterone, prasterone can improve libido and sexual satisfaction, which often decline during menopause.

Usage and Considerations

Prasterone is available in various forms, including oral supplements, topical creams, and vaginal inserts, which are particularly effective for addressing local symptoms like vaginal atrophy and dryness. The appropriate dosage of prasterone can vary widely, so it’s crucial to consult with a healthcare provider to determine the right amount based on individual health needs and existing hormone levels.

Side Effects and Considerations

While prasterone supplementation can offer significant benefits for menopausal women, it’s not suitable for everyone. Potential side effects may include oily skin, acne, hair loss, and changes in mood. Women with a history of hormone-sensitive cancers, such as breast or ovarian cancer, should use prasterone with caution, as it can influence hormone levels.

Conclusion

Prasterone presents a promising option for managing menopause symptoms, particularly for those looking to alleviate vaginal atrophy and improve sexual health. Its role in maintaining hormonal balance can help mitigate the diverse symptoms associated with menopause. However, due to its effects on hormone production, it is essential to approach prasterone supplementation under the guidance of a healthcare provider to ensure it is used safely and effectively.

References:

1. Prasterone[patient information PDF]. https://us.intrarosa.com/resources/intrarosa-patient-information-m.pdf 

The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care. This information should not be used to diagnose or treat any health problems or illnesses without consulting a doctor. Consult with a health care practitioner before relying on any information in this article or on this website.