*Content reviewed by HotPause Health Medical editorial board.
If you’ve been diagnosed with endometriosis, you’re already familiar with the chronic pain, fatigue, and frustration that can come with it. But new research adds another layer to the conversation: a statistically significant link between endometriosis and early natural menopause. In a landmark study published in JAMA researchers analyzed data from over 106,000 women and found that those with laparoscopically confirmed endometriosis had a 28–50% higher risk of entering menopause before age 45. That’s years—sometimes a decade or more—before the national average of 51.
What is Endometriosis?
Endometriosis is a chronic inflammatory condition where tissue similar to the uterine lining grows outside the uterus. It affects roughly 1 in 10 women during their reproductive years and is commonly associated with symptoms like pelvic pain, heavy periods, fatigue, infertility, and pain during sex. But a new conversation is emerging: could endometriosis also shorten your reproductive lifespan?
Why Does This Study On Endometriosis & Early Menopause Matter?
Early menopause shortens the reproductive window and has been linked to increased risks for cardiovascular disease, cognitive decline, osteoporosis, and more. For people already managing endometriosis, the possibility of an earlier hormonal shift raises important questions around fertility, symptom management, and long-term health.
Can Endometriosis Cause Early Menopause?
Experts believe the link may stem from a combination of factors: earlier age of menarche, chronic inflammation in the pelvic region, surgical treatments like endometrioma removal that reduce ovarian reserve, and underlying hormonal imbalances. Inflammation, in particular, may accelerate ovarian aging, disrupting the delicate balance required to sustain regular menstrual cycles.
Does This Mean If You Have Endometriosis, You’ll Go Through Menopause Early?
Not necessarily. While the study is one of the most comprehensive to date, it doesn't mean early menopause is a given for every patient with endometriosis. The greatest risk was seen in women who had never used oral contraceptives and who had never given birth. More research is needed to fully understand the mechanisms at play and what can be done to protect ovarian health.
What Should You Do If You Have Endometriosis?
Knowledge is power. If you’re managing endometriosis and starting to notice symptoms of perimenopause—irregular cycles, mood shifts, brain fog, or night sweats—it’s worth having a conversation with your provider. Your treatment plan might need to evolve, especially if you're considering fertility preservation or experiencing worsening symptoms.
