*Content reviewed by HotPause Health Medical Advisor & Doctor of Pharmacy Audrey Hou, PharmD, CMPP

Generically known as flibanserin, Addyi, is an FDA-approved medication specifically designed to treat Hypoactive Sexual Desire Disorder (HSDD) in pre-menopausal women. HSDD is characterized by a low sexual desire that is troubling to the individual, not attributable to existing medical or mental health issues, relationship problems, medication, or other drug use. HSDD is often experienced by an absence of sexual fantasies, thoughts, and/or desire for or receptivity to sexual activity.

How Addyi Works

Addyi is a non-hormonal medication that works by affecting the balance of certain neurotransmitters in the brain involved in sexual desire and inhibition. The exact mechanism is not fully understood, but it is thought to enhance the factors that promote sexual desire while inhibiting those that dampen it.

Who Should Use Addyi

Addyi is prescribed for women who have not yet undergone menopause and are experiencing low sexual desire not related to an existing medical condition, relationship issues, or as a side effect of other medications. It is important to note that Addyi is not suitable for treating HSDD in post-menopausal women or to enhance sexual performance.

Potential Benefits of Addyi for Menopause

• Many women start to experience improvements in their HSDD symptoms, such as increased sexual desire, reduced distress, and an increase in satisfying sexual events, as early as four weeks after beginning treatment with Addyi. However, it may take longer for some women to notice improvements. If no improvement is observed within eight weeks, discontinuation of the medication is recommended.

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Usage and Considerations

Addyi is taken once daily at bedtime. This consistent daily dosing helps manage the symptoms of HSDD effectively. It is not an on-demand medication, and skipping doses can affect its efficacy. If a dose is missed, it should be skipped and the next dose taken at the usual time the following night.

Side Effects and Considerations

Common side effects of Addyi include:

• Dizziness
• Difficulty falling asleep or staying asleep
• Nausea
• Dry mouth
• Tiredness

Due to its interaction with certain medications, Addyi can significantly increase in blood levels, leading to severe low blood pressure and fainting, particularly if mixed with alcohol. It is critical to inform your healthcare provider about all medications being taken, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Specific medications to avoid while on Addyi include certain antibiotics, antifungals, antivirals, and drugs used for treating high blood pressure and chest pain. Consult your pharmacist for a comprehensive review. Addyi should only be used by the patient group for which it is indicated, and it must be prescribed and used under the guidance of a healthcare provider familiar with its use and potential risks. Prior to starting treatment, a comprehensive medical evaluation should be conducted to confirm the diagnosis of HSDD and to check for any health conditions or medications that might contraindicate its use.

Conclusion

Addyi represents a significant advancement in the treatment of Hypoactive Sexual Desire Disorder for premenopausal women. By addressing the complex neurochemical factors influencing sexual desire, Addyi can help improve the quality of life for women experiencing HSDD. Like all medications, it is essential to use Addyi under the strict supervision of a healthcare provider to maximize benefits and minimize risks.